Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin damage produced by, for example, atopic dermatitis, burns, long term usage of topical steroids or eczema. It is also known as Kaposi varicelliform eruption, Pustulosis varioliformis acute and Kaposi-Juliusberg dermatitis.
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Eczema herpeticum (EH) 是一种由单纯疱疹病毒在特应性皮炎患者中引起的广泛皮肤感染。它通常突然出现,在湿疹常见部位出现水疱样水疱、糜烂并结痂。症状可能包括发热、淋巴结肿大或全身不适。 在健康成人中,EH 通常轻微且短暂;但在儿童、婴儿以及免疫功能低下者中,可能非常严重。尽早启动抗病毒治疗有助于缩短轻症病程并预防重症并发症。 Eczema herpeticum (EH) is a disseminated cutaneous infection with herpes simplex virus that develops in a patient with atopic dermatitis. EH typically presents as a sudden onset eruption of monomorphic vesicles and punched-out erosions with hemorrhagic crusts over eczematous areas. Patients may have systemic symptoms, such as fever, lymphadenopathy, or malaise. Presentation ranges from mild and self-limiting in healthy adults to life-threatening in children, infants, and immunocompromised patients. Early treatment with antiviral therapy can shorten the duration of mild disease and prevent morbidity and mortality in severe cases.
一名8岁、患有特应性皮炎的女孩来院时,出现大面积发痒、凸起的红色水泡,水泡中心有小凹痕。检查显示她感染了1型单纯疱疹病毒。 An 8-year-old girl with atopic dermatitis came in with a widespread outbreak of itchy, raised, red blisters with a small indentation in the center. Tests showed she had herpes simplex virus type 1.
该感染表现为特应性皮炎上叠加大量水泡,常伴发热和淋巴结肿大,且可危及婴儿生命。
大多数病例由单纯疱疹病毒引起,可采用全身抗病毒药物治疗,例如 Acyclovir(阿昔洛韦)。
○ 诊断和治疗
若误将其诊断为普通湿疹(如特应性皮炎)并使用类固醇软膏,可能会加重病情。
#Acyclovir
#Fancyclovir
#Valacyclovir